Entire Publications

Since 2023.

• 2024

• Kim J and Hwang JY, Intracellular domain of CATSPER1 could serve as a cytoplasmic platform for redox processes in mammalian sperm. Ani BioSci. 2024. DOI: https://doi.org/10.5713/ab.24.0631 

• Hwang JY, Sperm hyperactivation and the CatSper channel: current understanding and future contribution of domestic animals. J Anim Sci Technol. 2024.06; 66(3):443-456. DOI: https://doi.org/10.5187/jast.2023.e133

• Lee KH and Hwang JY, Ca2+ homeostasis and male fertility: a target for a new male contraceptive system. Anim. Cells. Syst. 2024.04; 28(1): 171-183. doi:10.1080/19768354.2024.2345647

• Hwang JY, Analysis of Ca2+-mediated sperm motility to evaluate the functional normality of the sperm-specific Ca2+ channel, CatSper. Front. in Cell and Dev Biol. 2024. 02. doi: 10.3389/fcell.2024.1284988.

• 2023

• Hwang JY†, Chai P†, Nawaz S†, Choi J, Lopez-Giraldez F, Hussain S, Bilguvar K, Mane S, Lifton PR, Ahmad W, Zhang K, and Chung JJ, LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility. eLife. 2023.12; 12:RP90095. doi: 10.7554/eLife.90095. †Equal contribution.

• Nand KN, Jordan TB, Yuan X, Basore DA, Zagorevski D, Clarke C, Werner G, Hwang JY, Wang H, Chung JJ , McKenna A, Jarvis MD, Singh G, Bystroff C, Bacterial production of recombinant contraceptive vaccine antigen from CatSper displayed on a human papilloma virus-like particle. Vaccine. 2023. S0264-410X(23)01114-3.

• Hwang JY and Chung JJ, CATSPER Calcium Channels: twenty years on. Physiology (Bethesda). 2023. 01; 38(3).

2012 - 2022.

• 2022

• Dou Q, Turanov AA, Mariotti M, Hwang JY, Wang H, Lee, SG, Paulo JA, Yim SH, Gygi SP, Chung JJ, and Gladyshev VN, TXNRD3 supports male fertility via the redox control of spermatogenesis, J Biol Chem. 2022;298(8):102183.

• Zhao Y, Wang H, Wiesehoefer C, Shah NB, Reetz E, Hwang JY, Huang X, Lishko PV, Davies KM, Wennemuth G, Nicastro D, Chung JJ, 3D structure and in situ arrangements of CatSper channel in the sperm flagellum, Nat Commun. 2022;13(1):3439.

• Hwang JY, Wang H, Lu Y, Ikawa M, Chung JJ, C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane, Cell Rep. 2022 Jan 18:110226. doi: 10.1016/j.celrep.2021.110226.

• 2021

• Jeong J, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung JJ, Yan Q, Liu Y, Choi J, Wysolmerski J, MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells, Cell Rep, 2021, 37(13):110160. doi: 10.1016/j.celrep.2021.110160.

• Hwang JY*, Maziarz J, Wagner GP, Chung JJ*, Molecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum, Cells. 2021;10(5):1047. *Corresponding authors.

• Hwang JY†, Nawaz S†, Choi J†, Wang H, Hussain S, Nawaz M, López-Giráldez F, Jeong K, Dong W, Oh JN, Bilguvar K, Mane S, Lee CK, Bystroff C, Lifton RP, Ahmad W, and Chung JJ, Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice, Front. Cell Dev. Biol. 2021; 9:662903. †Equal contribution.

• 2020

• Oh JN, Son D, Choi KH, Hwang JY, Lee DK, Kim SH, Lee M, Jeong J, Choe GC, and Lee CK, MicroRNA expression data of pluripotent and somatic cells and identification of cell type-specific MicroRNAs in pigs, Data Brief. 2020;33:106563.

• Ded L, Hwang JY, Miki K, Shi H, and Chung JJ, 3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice, eLife, 2020; 9:e62043.

• 2019

• Hwang JY, Mannowetz N, Zhang Y, Everley RA, Gygi SP, Bewersdorf J, Lishko PV, and Chung JJ, Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility, Cell, 2019; 177(6):1480-1494.

• Kim SH, Choi KH, Lee DK, Lee M, Hwang JY, and Lee CK, Identification and characterization of the OCT4 upstream regulatory region in Sus scrofa. Stem Cells International, 2019; 2019:2130973.

• Lee DK, Choi KH, Hwang JY, Oh JN, Kim SH, and Lee CK, Stearoyl-coenzyme A desaturase 1 is required for lipid droplet formation in pig embryo. Reproduction, 2019; 157(3):235-243.

• 2017

• Hwang JY and Chung JJ, Sex at atomic level. Cell. 2017; 169(7):1174-1176.

• Hwang JY and Lee CK, X-Chromosome Inactivation: A Complex Circuits regulated by Non-coding RNAs and Pluripotent Factors. Reprod Dev Biol. 2017; 41(2):33-40.

• Baek S, Lee ST, Hwang JY, Park KH, and Yun JI. Identification of capacitation inducers customized to sperm retrieved from inbred mouse epididymis. Biochemical Biophys Res Commun, 2017; 488(2):273-277.

• Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, and Clapham DE. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. eLife, 2017; 23;6. pii: e23082.

• Baek S, Han NR, Yun JI, Hwang JY, Kim M, Park CK, Lee E, and Lee ST. Effects of Culture Dimensions on Maintenance of Porcine Inner Cell Mass-Derived Cell Self-Renewal. Mol Cells, 2017; 40(2):117-122.

• Lee SG, Kaya A, Avanesov AS, Podolskiy DI, Song EJ, Go DM, Jin GD, Hwang JY, Kim EB, Kim DY, and Gladyshev VN. Age-associated molecular changes are deleterious and may modulate life span through diet. Sci Adv, 2017; 17;3(2):e1601833.

• 2016

• Lee DK, Park CH, Choi KH, Jeong YI, Uh KJ, Hwang JY, Lee SG, and Lee CK. Aggregation of cloned embryos in empty zona pellucida improves derivation efficiency of pig ES-like cells. Zygote, 2016; 24(6):909-917.

• Park MH, Park JE, Kim MS, Lee KY, Hwang JY, Yun JI, Choi JH, Lee E, Lee ST. Effects of extracellular matrix protein-derived signaling on the maintenance of the undifferentiated state of spermatogonial stem cells from porcine neonatal testis. Asian-Australas J Anim Sci, 2016; Vol. 29, No. 10 : 1398-1406.

• Hwang JY, Jin GD, Park J, Lee SG, Kim EB. Complete sequences of eastern water bat, Myotis petax (Chiroptera; Microchiroptera; Vespertilionidae) mitogenome. Mitochondrial DNA Part A, 2016; 27(5): 3715-3716.

• Lee H, Han NR, Hwang JY, Yun JI, Kim C, Park KH, and Lee ST. Gelatin Directly Enhances Neurogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stem Cells Without Stimulation of Neural Progenitor Cell Proliferation, DNA and Cell Biology, 2016; Vol. 35(9): 530-536.

• Hwang JY, Han GG, Park JY, Kim EM, An CM, Kang JH, Choi YJ, Kim EB. Complete sequence and polymorphisms of female Ruditapes philippinarum (Mollusca: Bivalvia) mitochondria genome. Mitochondrial DNA Part A, 2016; 27(5): 3462-3463.

• Kim SH, Choi KH, Lee DK, Oh JN, Hwang JY, Park CH, and Lee CK. Ginsenoside Rg1 improves in vitro-produced embryo quality by increasing glucose uptake in porcine blastocysts. Asian-Australas J Anim Sci, 2016; Vol. 29, No. 8: 1095-110.

• Hwang JY, Jin GD, Park J, Kim H, Lee CK, Kwak W, Nam BH, An CM, Park JY, Park KH, Huh CS, Kim EB. Complete genome sequence and SNPs of Raja pulchra (Rajiformes, Rajidae) mitochondria. Mitochondrial DNA Part A, 2016; 27(4): 2975–2977.

• Choi KH, Park JK, Son D, Hwang JY, Lee DK, Ka H, Park J, and Lee CK. Regeneration of Endogenous Genes and epigenetic remodeling are barriers for generating transgene-free induced pluripotent stem cells in pigs, PLoS One, 2016. 11(6): e0158046.

• Hwang JY, Lee S-G, Kim EB. Polymorphic sites in complete genome sequences of Asian badger, Meles leucurus amurensis (Mustelidae, Melinae) mitochondria. Mitochondrial DNA Part B, 2016;1(1): 264-265.

• Oh JN, Hwang JY, Choi KH, Lee CK. Treatment of aromatase (CYP19A1) inhibitor reduces fertility in porcine sperm. Zygote, 2016; 24: 98-106.

• 2015

• Hwang JY, Lee CK, Kim H, Nam BH, An CM, Park JY, Park KH, Huh CS, Kim EB. Comparative genomic analysis of mitochondrial protein-coding genes in Veneroida clams: Analysis of superfamily-specific genomic and evolutionary features. Mar Genomics, 2015; 24 Pt 3: 329-34.

• Hwang JY, Choi KH, Lee DK, Kim SH, Kim EB, Hyun SH, and Lee CK. Overexpression of OCT4A ortholog elevates endogenous XIST in porcine parthenogenic blastocysts. J Reprod Dev, 2015; 61: 533-40.

• Hwang JY, Choi K-H, Lee C-K. Data for identification of porcine X-chromosome inactivation center, XIC, by genomic comparison with human and mouse XIC. Data in Brief, 2015; 5: 1072-1077.

• Hwang JY, Oh JN, Park CH, Lee DK, and Lee CK. Dosage compensation of X-chromosome inactivation center-linked genes in porcine preimplantation embryos: Non-chromosome-wide initiation of X-chromosome inactivation in blastocysts. Mech Dev, 2015; 138 Pt 3: 246-55.

• Park CH, Jeong YH, Lee DK, Hwang JY, Uh KJ, Yeom SC, Ahn C, and Lee CK. Availability of Empty Zona Pellucida for Generating Embryonic Chimeras. PLoS One, 2015; 10: e0123178.

• Hwang JY, Oh JN, Lee DK, Choi KH, Park CH, and Lee CK. Identification and differential expression patterns of porcine OCT4 variants. Reproduction, 2015; 149: 55-66.

• 2014

• Park KD, Kim H, Hwang JY, Lee CK, Do KT, Kim HS, Yang YM, Kwon YJ, Kim J, Kim HJ, Song KD, Oh JD, Kim H, Cho BW, Cho S, Lee HK. Copy number deletion has little impact on gene expression levels in racehorses. Asian-Australas J Anim Sci, 2014; 27: 1345-54.

• Son DC, Hwang JY, Lee CK. Identification of Candidate Porcine miRNA-302/367 Cluster and Its Function in Somatic Cell Reprogramming. Reproductive Developmental Biology, 2014; 38.

• Shin DH, Lee HJ, Cho S, Kim HJ, Hwang JY, Lee CK, Jeong J, Yoon D, Kim H. Deleted copy number variation of Hanwoo and Holstein using next generation sequencing at the population level. BMC Genomics, 2014; 15: 240.

• Park W, Kim J, Kim HJ, Choi J, Park JW, Cho HW, Kim BW, Park MH, Shin TS, Cho SK, Park JK, Kim H, Hwang JY, Lee CK, Lee HK, Cho S, Cho BW. Investigation of de novo unique differentially expressed genes related to evolution in exercise response during domestication in Thoroughbred race horses. PLoS One, 2014; 9: e91418.

• 2013

• Hwang JY, Kim EB, Ka H, Lee CK. Identification of the porcine XIST gene and its differential CpG methylation status in male and female pig cells. PLoS One, 2013; 8: e73677.

• Hwang JY, Mulligan BP, Kim HM, Yang BC, Lee CK. Quantitative analysis of sperm mRNA in the pig: relationship with early embryo development and capacitation. Reprod Fertil Dev, 2013; 25: 807-17.

• Lee HJ, Jang M, Kim H, Kwak W, Park W, Hwang JY, Lee CK, Jang GW, Park MN, Kim HC, Jeong JY, Seo KS, Kim H, Cho S, Lee BY. Comparative Transcriptome Analysis of Adipose Tissues Reveals that ECM-Receptor Interaction Is Involved in the Depot-Specific Adipogenesis in Cattle. PLoS One, 2013; 8: e66267.

• 2012

• Mulligan B, Hwang JY, Kim HM, Oh JN, Choi KH, Lee CK. Pro-apoptotic Effect of Pifithrin-alpha on Preimplantation Porcine In vitro Fertilized Embryo Development. Asian-Australas J Anim Sci, 2012; 25: 1681-90.